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Radiation enteropathy; Radiation-induced small bowel injury; Post-radiation enteritis
Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells.
Along with the cancer cells, radiation therapy may also damage cells that make up the lining of the intestines.
Anyone who receives radiation therapy to the belly or pelvic area is at risk. This may include people with cervical, pancreatic, prostate, uterine, or colon and rectal cancer.
Symptoms may be different depending on what part of the intestines received the radiation. They can first occur during or shortly after radiation treatment (called acute radiation enteritis), or long after the treatment.
Changes in bowel movements may include:
Other symptoms can include:
Most of the time, these symptoms get better within 2 - 3 months after radiation treatment ends.
When symptoms become long-term (chronic), other problems may include:
The health care provider will do a physical exam and ask you questions about your medical history.
Tests may include:
Starting a low-fiber diet on the first day of radiation treatment can be helpful. The best choice of foods depends on what symptoms you have.
Avoiding the following foods may help with symptoms:
Foods and drinks that are better choices include:
Other ways to control the symptoms of radiation enteritis include:
Your doctor may suggest or prescribe certain medications:
Drink plenty of fluids (up to 12 8-ounce glasses) every day when you have diarrhea. Some people need fluids given through a vein (intravenous fluids).
Your health care provider may choose to stop or reduce the dosage of radiation for a short period of time.
There often are no good treatments for chronic radiation enteritis. However, medications such as cholestyramine, diphenoxylate-atropine, loperamide, or sucralfate may be helpful. Your doctor may discuss surgery to either remove or go around (bypass) a section of damaged intestine.
When the abdomen receives radiation, there is always some nausea, vomiting, and diarrhea. In most cases, the symptoms get better within 2 - 3 months after treatment ends.
However, when this condition develops, symptoms may last for a long period of time. Long-term (chronic) enteritis is rarely curable.
Call your health care provider if you are undergoing radiation therapy or have had radiation in the past and are experiencing a lot of diarrhea or stomach pain and cramping.
Czito BG, Willett CG. Radiation injury. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier;2010: chap 39.
National Cancer Institute. Gastrointestinal Complications PDQ. Updated July 18, 2012.
Prather C. Inflammatory and anatomic diseases of the intestine, peritoneum, mesentery, and omentum. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 144.